IL16 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comIL16 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > IL16(Gene name) > Human

IL16 (Gene name),

Pro-interleukin-16 (Protein name ), IL16_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

IL16;

Protein name:

Pro-interleukin-16;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). Isoform 3 interacts with HTLV-1 tax.

Function:

Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Subcellular Location:

Isoform 3 Cytoplasm Nucleus

Protein Attributes:

Sequence length:

1332

Sequence:

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1332:

WNIIKALPDG | PVTIVIRRKS | LQSKETTAAG | DS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:3603

String:

Q14005

UniGene:

Hs.459095

Pfam:

PF00595

STRING:

9606.ENSP00000302935

SMR:

Q14005

MIM:

603035

Uniprot:

Q14005

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ELISA Kit for Human Pro-interleukin-16

Cat.:

E0062b

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MSDS:

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Packing:

96T

ELISA Kit for Human Pro-interleukin-16

Cat.:

E0062h

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Packing:

96T

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ELISA Kit for Human Pro-interleukin-16

Cat.:

E0062m

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96T

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CLIA Kit for Human Pro-interleukin-16

Cat.:

U0062h

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Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Pro-interleukin-16

Cat.:

U0062m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Pro-interleukin-16

Cat.:

U0062b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Pro-interleukin-16

Cat.:

P0062Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Pro-interleukin-16

Cat.:

P0062Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Pro-interleukin-16

Protein for Human Pro-interleukin-16

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer"

LB Gao, L Rao, YY Wang, et al.

From:Carcinogenesis

References

1.

"PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits."
Bannert N. , Vollhardt K. , Asomuddinov B. , Haag M. , Koenig H. , Norley S. , Kurth R.
J. Biol. Chem.278:42190-42199(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH PPP1R12A; PPP1R12B; PPP1R12C AND GRIN2A
2.

"Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."
Wang P. , Yu P. , Gao P. , Shi T. , Ma D.
BMC Genomics10:518-518(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
3.

Kornfeld H.
Submitted (1999-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Peripheral blood.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Cerebellum.
5.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
7.

"GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes."
Bannert N. , Avots A. , Baier M. , Serfling E. , Kurth R.
Proc. Natl. Acad. Sci. U.S.A.96:1541-1546(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 685-1332
8.

SeattleSNPs variation discovery resource
Submitted (2003-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 685-1332;VARIANTS GLN-889; LEU-906 AND LYS-1147
9.

"Interleukin-16 or not?"
Bannert N. , Baier M. , Werner A. , Kurth R.
Nature381:30-30(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 942-1332
10.

"Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression."
Cruikshank W.W. , Center D.M. , Nisar N. , Wu M. , Natke B.C. , Theodore A.C. , Kornfeld H.
Proc. Natl. Acad. Sci. U.S.A.91:5109-5113(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1203-1332;SUBUNIT
tissue: Peripheral blood.
11.

"Cloning, expression and purification of human interleukin-16."
Du Y. , Du G.X. , Hou L.H. , Wang H.T.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi15:25-27(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1203-1332
12.

"Processing and activation of pro-interleukin-16 by caspase-3."
Zhang Y. , Center D.M. , Wu D.M. , Cruikshank W.W. , Yuan J. , Andrews D.W. , Kornfeld H.
J. Biol. Chem.273:1144-1149(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1212-1220;PROTEOLYTIC PROCESSING;MUTAGENESIS OF ASP-1211
13.

"Nuclear translocation of the N-terminal prodomain of interleukin-16."
Zhang Y. , Kornfeld H. , Cruikshank W.W. , Kim S. , Reardon C.C. , Center D.M.
J. Biol. Chem.276:1299-1303(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION (PRO-INTERLEUKIN-16);MUTAGENESIS OF 780-LYS-LYS-781 AND 797-LYS--ARG-802
14.

"Gene regulation mediated by calcium signals in T lymphocytes."
Feske S. , Giltnane J. , Dolmetsch R. , Staudt L.M. , Rao A.
Nat. Immunol.2:316-324(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
15.

"Prointerleukin-16 contains a functional CcN motif that regulates nuclear localization."
Wilson K.C. , Cruikshank W.W. , Center D.M. , Zhang Y.
Biochemistry41:14306-14312(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;MUTAGENESIS OF SER-743 AND THR-757
16.

"Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein."
Wilson K.C. , Center D.M. , Cruikshank W.W. , Zhang Y.
Virology306:60-67(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTLV-1 TAX;SUBCELLULAR LOCATION
17.

"Nuclear pro-IL-16 regulation of T cell proliferation: p27(KIP1)-dependent G0/G1 arrest mediated by inhibition of Skp2 transcription."
Center D.M. , Cruikshank W.W. , Zhang Y.
J. Immunol.172:1654-1660(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (PRO-INTERLEUKIN-16);SUBCELLULAR LOCATION
18.

"Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP."
Zhang Y. , Tuzova M. , Xiao Z.X. , Cruikshank W.W. , Center D.M.
J. Immunol.180:402-408(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (PRO-INTERLEUKIN-16);SUBCELLULAR LOCATION (PRO-INTERLEUKIN-16);INTERACTION WITH GABPB1 AND HDAC3
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site."
Muehlhahn P. , Zweckstetter M. , Georgescu J. , Ciosto C. , Renner C. , Lanzendoerfer M. , Lang K. , Ambrosius D. , Baier M. , Kurth R. , Holak T.A.
Nat. Struct. Biol.5:682-686(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1203-1332
21.

"Solution structures of the PDZ domain of human interleukin-16."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1103-1209

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